What Paradigm Shifts should I add to my clicker game?

For anyone who doesn’t know, a Paradigm Shift means (example based off how I want to use it) when a game adds a new big new mechanic on top of the other mechanics, which can shift your goal or/and how you play. A prestige/rebirth is a basic example of this, but a great example I know of is the Grandma Apocalypse in Cookie Clicker. I’m also making a clicker game, and I want to add some Paradigm Shifts to my game to make it better and less repetitive.
Leave your ideas in the comments below

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e.g. rebirths?
random-ish “boss” levels?

deduction of cookies at an interval, making it a survival game?

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